Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.52 |
| ▸ | EDNRA | P25101 | 2/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553011 | 0.93 | EDNRB (0.51) | EDNRBEDNRAPLA2G2AKDM4EALDH1A1 | |
| SCHEMBL8549015 | 0.92 | EDNRB (0.50) | EDNRBEDNRASMN1; SMN2MAPTHTT | |
| SCHEMBL8553494 | 0.91 | EDNRB (0.52) | EDNRBEDNRASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8547582 | 0.90 | EDNRB (0.52) | EDNRBEDNRASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8551194 | 0.88 | EDNRB (0.64) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8550887 | 0.88 | EDNRB (0.58) | EDNRBEDNRASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8552686 | 0.86 | EDNRB (0.53) | EDNRBEDNRASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8547527 | 0.85 | EDNRB (0.48) | EDNRBEDNRASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8549175 | 0.85 | EDNRB (0.59) | EDNRBEDNRAGAA | |
| SCHEMBL8550230 | 0.84 | EDNRB (0.66) | EDNRBEDNRAPLA2G2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |