Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.50 |
| ▸ | EDNRA | P25101 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551196 | 0.92 | EDNRB (0.52) | EDNRBEDNRAALDH1A1MAPTHTT | |
| SCHEMBL8553011 | 0.91 | EDNRB (0.51) | EDNRBEDNRAALDH1A1HPGD | |
| SCHEMBL8549014 | 0.89 | EDNRB (0.61) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8551027 | 0.88 | EDNRB (0.53) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8553494 | 0.87 | EDNRB (0.52) | EDNRBEDNRAALDH1A1TP53MAPT | |
| SCHEMBL8553797 | 0.86 | EDNRB (0.55) | EDNRBEDNRA | |
| SCHEMBL8551432 | 0.86 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8547582 | 0.84 | EDNRB (0.52) | EDNRBEDNRAMAPTSMN1; SMN2 | |
| SCHEMBL8552686 | 0.82 | EDNRB (0.53) | EDNRBEDNRAMAPTSMN1; SMN2 | |
| SCHEMBL8550887 | 0.82 | EDNRB (0.58) | EDNRBEDNRAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |