Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.73 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15883219 | 0.98 | HDAC3 (0.73) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL23540107 | 0.93 | HDAC3 (0.70) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL517697 | 0.89 | HDAC3 (0.86) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL29111436 | 0.86 | HDAC1 (0.56) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL19962693 | 0.86 | POLB (0.68) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL17252159 | 0.85 | HDAC3 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL2531377 | 0.85 | HDAC3 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL2319941 | 0.85 | HDAC3 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL22479429 | 0.85 | MEN1 (0.61) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL13524769 | 0.85 | HDAC1 (1.00) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660832-B1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMA INC (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5436246-A | Compounds for treatment of anxiety, depression, migraine, stroke, angina and hypertension | MERRELL DOW PHARMACEUTICALS INC. | 1995-07-25 | — | — | US | disclosed |
| EP-0660832-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006789-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-31 | — | — | WO | disclosed |