Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.47 |
| ▸ | EDNRA | P25101 | 5/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547310 | 0.94 | EDNRB (0.47) | EDNRBEDNRAAGTR2AGTR1KMT2A | |
| SCHEMBL8552691 | 0.92 | EDNRB (0.43) | EDNRBEDNRAAGTR2AGTR1KMT2A | |
| SCHEMBL8591727 | 0.92 | EDNRB (0.56) | EDNRBEDNRAAGTR2KMT2APOLB | |
| SCHEMBL8552260 | 0.91 | EDNRB (0.47) | EDNRBEDNRAAGTR2AGTR1 | |
| SCHEMBL8550816 | 0.90 | EDNRB (0.43) | EDNRBEDNRAAGTR2AGTR1 | |
| SCHEMBL8551303 | 0.90 | EDNRB (0.59) | EDNRBEDNRAAGTR2AGTR1 | |
| SCHEMBL8549515 | 0.89 | EDNRB (0.47) | EDNRBEDNRAAGTR2AGTR1KMT2A | |
| SCHEMBL8655565 | 0.89 | EDNRB (0.45) | EDNRBEDNRAAGTR2AGTR1 | |
| SCHEMBL8548125 | 0.88 | EDNRB (0.45) | EDNRBEDNRAAGTR2AGTR1KMT2A | |
| SCHEMBL8551968 | 0.87 | EDNRB (0.55) | EDNRBEDNRAKMT2APOLBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |