SCHEMBL8551439

SCHEMBL8551439

Clc1ccc(OCc2nc3c(CCCC4CCCNC4)cccc3[nH]2)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NPY1R P25929 15/20 0.42
ACP1 P24666 2/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8553133 0.91 NPY1R (0.42) NPY1RACP1
SCHEMBL8554917 0.88 NPY1R (0.44) NPY1RRAB9A
SCHEMBL8555787 0.87 NPY1R (0.40) NPY1RACP1
SCHEMBL8554205 0.85 NPY1R (0.39) NPY1RACP1NPC1RAB9A
SCHEMBL8554293 0.83 NPY1R (0.43) NPY1RACP1NPC1RAB9A
SCHEMBL8551506 0.81 NPY1R (0.43) NPY1RACP1
Trifluoroacetic Acid SCHEMBL8552860 0.81 NPY1R (0.48) NPY1R
Trifluoroacetic Acid SCHEMBL8553079 0.77 NPC1 (0.38) NPC1RAB9A
SCHEMBL8553363 0.76 NPY1R (0.48) NPY1RACP1
SCHEMBL8554556 0.76 NPY1R (0.51) NPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871442-A1 BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1998-10-21 EP disclosed
WO-1997025041-A1 BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1997-07-17 WO disclosed