Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 16/20 | 0.58 |
| ▸ | EDNRA | P25101 | 12/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552564 | 0.93 | EDNRB (0.66) | EDNRBEDNRATP53POLB | |
| SCHEMBL8547214 | 0.91 | EDNRB (0.56) | EDNRBEDNRATP53POLB | |
| SCHEMBL8551023 | 0.91 | EDNRB (0.67) | EDNRBEDNRATP53PLK1CSF1R | |
| SCHEMBL8549315 | 0.89 | EDNRB (0.64) | EDNRBEDNRATP53POLB | |
| SCHEMBL8551476 | 0.89 | EDNRB (0.48) | EDNRBEDNRAPLK1POLBCSF1R | |
| SCHEMBL8552951 | 0.85 | EDNRB (0.66) | EDNRBEDNRACSF1R | |
| SCHEMBL8550894 | 0.85 | EDNRB (0.59) | EDNRBEDNRATP53 | |
| SCHEMBL8548858 | 0.85 | EDNRB (0.45) | EDNRBEDNRAPLK1POLBCSF1R | |
| SCHEMBL8550885 | 0.83 | EDNRB (0.74) | EDNRBEDNRATP53 | |
| SCHEMBL8548412 | 0.83 | EDNRB (0.62) | EDNRBEDNRATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |