Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.45 |
| ▸ | EDNRA | P25101 | 7/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551476 | 0.95 | EDNRB (0.48) | EDNRBEDNRACSF1RPLK1KDM4E | |
| SCHEMBL8547864 | 0.94 | EDNRB (0.49) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8549318 | 0.93 | EDNRB (0.43) | EDNRBEDNRAPTPN1CSF1RPLK1 | |
| SCHEMBL8547859 | 0.91 | EDNRB (0.44) | EDNRBEDNRAPTPN1FFAR1 | |
| SCHEMBL8548187 | 0.89 | EDNRB (0.46) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8551027 | 0.88 | EDNRB (0.53) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8552566 | 0.88 | EDNRB (0.53) | EDNRBEDNRAKDM4EPOLBMAPT | |
| SCHEMBL8547217 | 0.87 | EDNRB (0.46) | EDNRBEDNRAKDM4EPOLBMAPT | |
| SCHEMBL8549316 | 0.86 | EDNRB (0.52) | EDNRBEDNRAMAPT | |
| SCHEMBL8547930 | 0.86 | EDNRB (0.47) | EDNRBEDNRAPTPN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |