Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.45 |
| ▸ | PDE5A | O76074 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | EDNRA | P25101 | 4/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551761 | 0.92 | EDNRB (0.49) | EDNRBEDNRADYRK1APLA2G2A | |
| SCHEMBL8553797 | 0.91 | EDNRB (0.55) | EDNRBEDNRADYRK1APLA2G2A | |
| SCHEMBL8551612 | 0.89 | EDNRB (0.58) | EDNRBPDE5APDE4APDE4BPDE4C | |
| SCHEMBL8551281 | 0.89 | EDNRB (0.49) | EDNRBEDNRADYRK1A | |
| SCHEMBL8547217 | 0.89 | EDNRB (0.46) | EDNRBEDNRADYRK1APLA2G2A | |
| SCHEMBL8620818 | 0.87 | EDNRB (0.46) | EDNRBEDNRADYRK1APLA2G2A | |
| SCHEMBL8549201 | 0.86 | EDNRB (0.40) | EDNRBPDE5APDE4APDE4BPDE4C | |
| SCHEMBL8617491 | 0.85 | EDNRB (0.45) | EDNRBEDNRADYRK1APLA2G2A | |
| SCHEMBL8547859 | 0.84 | EDNRB (0.44) | EDNRBEDNRADYRK1APLA2G2A | |
| SCHEMBL8551432 | 0.84 | EDNRB (0.64) | EDNRBEDNRAPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |