SCHEMBL8551641

SCHEMBL8551641

NC(=S)C(N)c1cccs1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.43
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
KEAP1 Q14145 1/20 0.39
TSHR P16473 1/20 0.36
CTSL P07711 2/20 0.35
MAPT P10636 3/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
ALDH1A1 P00352 1/20 0.33
PKM P14618 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
ATM Q13315 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HSD17B10 Q99714 2/20 0.33
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5027606 0.79 ALOX5 (0.51) ALOX5CES2CES1KEAP1TSHR
SCHEMBL13163250 0.79 ALOX5 (0.51) ALOX5CES2CES1KEAP1TSHR
SCHEMBL891673 0.75 ALOX5 (0.47) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL1527327 0.75 ALOX5 (0.47) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL10349140 0.75 ALOX5 (0.47) ALOX5CES2CES1KEAP1TSHR
SCHEMBL1527335 0.75 ALOX5 (0.47) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL10821329 0.73 ALOX5 (0.46) ALOX5CES2CES1KEAP1TSHR
Hydrochloric Acid SCHEMBL3891233 0.73 ALOX5 (0.46) ALOX5CES2CES1KEAP1MAPT
SCHEMBL12311239 0.73 ALOX5 (0.42) ALOX5CES2CES1KEAP1TSHR
SCHEMBL13592550 0.73 ALOX5 (0.42) ALOX5CES2CES1KEAP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4124172-A None JP disclosed
EP-0639574-B1 2-aminothiazolecarboxamide derivatives, processes for their preparation and their use for controlling phytopathogenic organisms LUCKY LTD (KR) 1998-06-10 EP disclosed
US-5514643-A FUNGICIDES FOR PLANTS LUCKY LTD. (KR) 1996-05-07 US disclosed
EP-0639574-A1 2-aminothiazolecarboxamide derivatives, processes for their preparation and their use for controlling phytopathogenic organisms LUCKY LTD. (KR) 1995-02-22 EP disclosed
JP-H04124172-A ALPHA-AMINO-THIOACETAMIDE DERIVATIVE AND ITS PRODUCTION NISSAN CHEM IND LTD 1992-04-24 JP disclosed