SCHEMBL8551674

SCHEMBL8551674

C[C@@H](C(=O)O)[C@@]1(c2ccc(F)cc2F)CO1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 1/20 0.44
HCAR2 Q8TDS4 1/20 0.44
CNR1 P21554 3/20 0.38
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC4 P56524 1/20 0.36
DPP4 P27487 1/20 0.36
DPP8 Q6V1X1 1/20 0.36
DPP9 Q86TI2 1/20 0.36
DPP7 Q9UHL4 1/20 0.36
AKR1B1 P15121 2/20 0.36
RECQL P46063 1/20 0.35
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
MC4R P32245 1/20 0.35
HTT P42858 1/20 0.35
PKM P14618 1/20 0.34
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8700904 1.00 HCAR3 (0.44) HCAR3HCAR2CNR1HDAC3HDAC1
SCHEMBL7684896 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL20970623 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL8718596 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL30485107 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL939090 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL1828008 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL1828149 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL30485088 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4
SCHEMBL2567128 0.81 HCAR3 (0.38) HCAR3HCAR2CNR1HDAC4DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617031-B1 Orally active azole derivates URIACH & CIA SA J (ES) 1998-09-16 EP disclosed
US-5478826-A Fungicides for human, animal and plants J. URIACH & CIA. S.A. (ES) 1995-12-26 US disclosed