Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15133186 | 1.00 | HDAC8 (0.41) | HDAC8DDB1CRBNPOLBMAOB | |
| SCHEMBL1177522 | 1.00 | HDAC8 (0.41) | HDAC8DDB1CRBNPOLBMAOB | |
| SCHEMBL4229835 | 0.87 | MEN1 (0.49) | MAOB | |
| SCHEMBL1177304 | 0.84 | MAOB (0.40) | MAOBTSHRHTT | |
| SCHEMBL1177018 | 0.84 | CACNA1C (0.34) | HDAC8POLB | |
| SCHEMBL23459347 | 0.84 | DDB1 (0.42) | HDAC8DDB1CRBNPOLBMAOB | |
| SCHEMBL18577187 | 0.84 | MAOB (0.40) | MAOBTSHRHTT | |
| SCHEMBL1193827 | 0.84 | FASN (0.42) | PLG | |
| SCHEMBL23459345 | 0.84 | DDB1 (0.42) | HDAC8DDB1CRBNPOLBMAOB | |
| SCHEMBL4229753 | 0.84 | CAPN1 (0.38) | HDAC8CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1045597-C | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1999-10-13 | — | — | CN | disclosed |
| US-5852006-A | N-aminoalkyl-substituted nitrogen-containing six membered heterocyclic compounds | NIPPON CHEMIPHAR CO., LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0579169-B1 | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5574030-A | INHIBITING URINARY CONTRACTION, HETEROCYCLIC DIAMINES | NIPPON CHEMIPHAR CO., LTD. (JP) | 1996-11-12 | — | — | US | disclosed |
| CN-1092412-A | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1994-09-21 | — | — | CN | disclosed |
| EP-0579169-A1 | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |
| US-4596819-A | Antidepressive agents | WARNER-LAMBERT COMPANY (US) | 1986-06-24 | — | — | US | disclosed |