SCHEMBL8551769

SCHEMBL8551769

O=[N+]([O-])c1cccc(Cl)c1C=CCSCC=Cc1c(Cl)cccc1[N+](=O)[O-]

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.46
HPGD P15428 2/20 0.40
ALDH1A1 P00352 8/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
KDM4E B2RXH2 2/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 6/20 0.38
MAPK1 P28482 3/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
TDP1 Q9NUW8 3/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
PKM P14618 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
GPR35 Q9HC97 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27168526 0.83 HSP90AA1 (0.47) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL25201635 0.78 HSP90AA1 (0.51) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL103575 0.75 TDP1 (0.59) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL11001165 0.74 HSP90AA1 (0.47) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL27168531 0.74 HSP90AA1 (0.47) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL29706339 0.74 HSP90AA1 (0.47) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL11001172 0.74 HSP90AA1 (0.47) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL9775507 0.74 HSP90AA1 (0.50) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL25529539 0.74 HSP90AA1 (0.50) HSP90AA1HPGDALDH1A1CYP1A2CYP2C9
SCHEMBL8759865 0.72 TSHR (0.39) HSP90AA1ALDH1A1KDM4EMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0711754-B1 Process for preparing 2-chloro-6-nitrophenylalkylsulfides as well as novel 2-chloro-6-nitrophenyl alkylsulfides BAYER AG (DE) 1999-03-10 EP disclosed
EP-0711754-A1 Process for preparing 2-chloro-6-nitrophenylalkylsulfides as well as novel 2-chloro-6-nitrophenyl alkylsulfides BAYER AG (DE) 1996-05-15 EP disclosed