⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585119 | 0.87 | ANPEP (0.48) | — | |
| SCHEMBL19357452 | 0.80 | — | — | |
| SCHEMBL12118194 | 0.78 | ANPEP (0.42) | — | |
| SCHEMBL15514478 | 0.78 | LMNA (0.36) | — | |
| SCHEMBL13078699 | 0.78 | — | — | |
| SCHEMBL9190882 | 0.78 | — | — | |
| SCHEMBL24965252 | 0.76 | CACNA2D1 (0.47) | — | |
| SCHEMBL805253 | 0.76 | ANPEP (0.41) | — | |
| SCHEMBL17772961 | 0.76 | ANPEP (0.41) | — | |
| SCHEMBL13851759 | 0.76 | CACNA2D1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133179-B2 | 2-methoxy-pyridin-4-yl-derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-09-15 | — | — | US | disclosed |
| EP-2665720-B1 | 2-METHOXY-PYRIDIN-4-YL DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2015-06-10 | — | — | EP | disclosed |
| US-20130303514-A1 | 2-METHOXY-PYRIDIN-4-YL-DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-11-14 | — | — | US | disclosed |
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |
| US-4927451-A | HERBICIDES | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0034647-B1 | 4-ARYLOXY-3-PHENYLPIPERIDINE DERIVATIVES, INTERMEDIATES, A PROCESS FOR THE PREPARATION OF SUCH COMPOUNDS AND THEIR USE AS MEDICAMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-06-05 | — | — | EP | disclosed |
| US-4424357-A | Process for preparing 4-aryloxy-3-phenylpiperidines | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1984-01-03 | — | — | US | disclosed |
| US-4382141-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-05-03 | — | — | US | disclosed |
| US-4312876-A | CENTRAL NERVOUS SYSTEM | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-01-26 | — | — | US | disclosed |
| US-4302590-A | THE 4-HYDROXY DERIVATIVE; ANALGESICS, ANTIDEPRESSANTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-11-24 | — | — | US | disclosed |
| EP-0034647-A2 | 4-Aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-02 | — | — | EP | disclosed |
| EP-0014997-A1 | 4-Aryloxy- and 4-arylthio-3-phenylpiperidine derivatives, a process for the preparation of such compounds and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-09-03 | — | — | EP | disclosed |
| US-4216218-A | Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-08-05 | — | — | US | disclosed |