Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 2/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547845 | 0.79 | ITGB3 (0.52) | ITGB3ITGA2B | |
| SCHEMBL7425992 | 0.77 | SYK (0.58) | MAPTSYKPOLBMAPK1KLK7 | |
| SCHEMBL7424195 | 0.77 | SYK (0.58) | MAPTSYKPOLBMAPK1KLK7 | |
| SCHEMBL21900169 | 0.76 | SIRT2 (0.60) | MAPTSYKKLK7KLK5SIRT2 | |
| SCHEMBL19295560 | 0.76 | SIRT2 (0.60) | MAPTSYKKLK7KLK5SIRT2 | |
| SCHEMBL21900170 | 0.76 | SIRT2 (0.60) | MAPTSYKKLK7KLK5SIRT2 | |
| SCHEMBL13430768 | 0.76 | SIRT2 (0.64) | MAPTSYKKLK7KLK5SIRT2 | |
| SCHEMBL30043940 | 0.76 | SIRT2 (0.64) | MAPTSYKKLK7KLK5SIRT2 | |
| SCHEMBL7406992 | 0.75 | SYK (0.49) | MAPTSYKPOLBMAPK1KLK7 | |
| SCHEMBL14561127 | 0.74 | SYK (0.61) | MAPTSYKKLK7KLK5SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828737-A1 | ISOXAZOLINE AND ISOXAZOLE DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-03-18 | — | — | EP | disclosed |