Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 14/20 | 0.63 |
| ▸ | CTSL | P07711 | 13/20 | 0.63 |
| ▸ | CTSB | P07858 | 9/20 | 0.62 |
| ▸ | CTSK | P43235 | 9/20 | 0.62 |
| ▸ | TACR1 | P25103 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552093 | 1.00 | CTSS (0.63) | CTSSCTSLCTSBCTSKTACR1 | |
| Cyclopropane SCHEMBL20526945 | 0.96 | CTSS (0.59) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL24249557 | 0.86 | CTSS (0.60) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL19386320 | 0.83 | CTSS (0.61) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL6560575 | 0.83 | CTSS (0.64) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL6560581 | 0.83 | CTSS (0.64) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL6311738 | 0.82 | CTSS (0.62) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL6312473 | 0.82 | CTSS (0.62) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL6311732 | 0.82 | CTSS (0.62) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL13534727 | 0.82 | NPC1 (0.65) | CTSSCTSLCTSBCTSKTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |