SCHEMBL8552305

SCHEMBL8552305

CCCCC(CCC)C(=O)N(C)OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 7/20 0.47
CA1 P00915 4/20 0.47
MAPK1 P28482 1/20 0.42
CHRM1 P11229 1/20 0.39
AKR1A1 P14550 1/20 0.39
CHRM3 P20309 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
ADRA1A P35348 1/20 0.39
HRH1 P35367 1/20 0.39
DRD3 P35462 1/20 0.39
SLC6A3 Q01959 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC2 Q92769 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP3A4 P08684 2/20 0.38
TSHR P16473 2/20 0.38
NFKB1 P19838 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
PDF Q9HBH1 4/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14531594 0.91 CA2 (0.50) CA2CA1MAPK1SLC1A2SLC1A1
SCHEMBL25914745 0.89 CA2 (0.47) CA2CA1MAPK1SLC1A2SLC1A1
SCHEMBL21625667 0.89 CA2 (0.56) CA2CA1MAPK1TDP1CYP3A4
SCHEMBL14996257 0.89 CA2 (0.56) CA2CA1MAPK1TDP1CYP3A4
SCHEMBL18641689 0.89 CA2 (0.47) CA2CA1MAPK1SLC1A2SLC1A1
SCHEMBL21095498 0.85 HDAC1 (0.41) CA2CA1MAPK1CHRM1AKR1A1
SCHEMBL21231691 0.84 TSHR (0.36) CA2CA1CHRM1AKR1A1CHRM3
SCHEMBL23178056 0.80 CA2 (0.48) CA2CA1MAPK1CHRM1AKR1A1
SCHEMBL18099967 0.79 CA1 (0.42) CA2CA1MAPK1TDP1CYP3A4
SCHEMBL6500352 0.78 DPP7 (0.43) CA2CA1SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5712287-A WITH 1,2,5-THIADIAZOLE OR 1,2,5-OXADIAZOLE AZABICYCLIC DERIVATIVES MUHLHAUSER MARK A (US) 1998-01-27 US disclosed
US-5712271-A OXADIAZOLE OR THIADIAZOLE COMPOUNDS SUBSTITUTED WITH AZABICYCLO(3.3.1)NONANE RING MUHLHAUSER MARK A (US) 1998-01-27 US disclosed
US-5710151-A ADMINISTERING A THIADIAZOLE OR AN OXADIAZOLE DERIVATIVE TO A SUBJECT MUHLHAUSER MARK A (US) 1998-01-20 US disclosed
US-5679686-A TREATING SCHIZOPHRENIA BY ADMINISTERING THIADIAZOLE OR OXADIAZOLE DERIVATIVES NOVO NORDISK A/S (DK) 1997-10-21 US disclosed
US-5677313-A ADMINISTERING 1,2,5-THIADIAZOLYL-AZABICYCLONONENE DERIVATIVES NOVO NORDISK A/S (DK) 1997-10-14 US disclosed