Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.48 |
| ▸ | FBP1 | P09467 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978607 | 0.85 | EGFR (0.60) | EGFRKDRERBB2ABCG2ERBB4 | |
| SCHEMBL7966689 | 0.85 | RET (0.62) | EGFRKDRERBB2ABCG2ATM | |
| SCHEMBL7966576 | 0.82 | EGFR (0.57) | EGFRKDRERBB2CYP1A2CYP3A4 | |
| SCHEMBL7977085 | 0.81 | EGFR (0.72) | EGFRKDRERBB2FBP1KDM4E | |
| SCHEMBL7980588 | 0.79 | RET (0.61) | EGFRKDRERBB2ABCG2ATM | |
| SCHEMBL7977034 | 0.77 | EGFR (0.54) | EGFRKDRERBB2FBP1GAK | |
| SCHEMBL4383397 | 0.76 | RET (0.70) | EGFRKDRERBB2GAKABCG2 | |
| Hydrochloric Acid SCHEMBL4377353 | 0.75 | RET (0.69) | EGFRKDRERBB2GAKABCG2 | |
| SCHEMBL7980461 | 0.75 | EGFR (0.61) | EGFRKDRERBB2GAKABCG2 | |
| SCHEMBL7966561 | 0.74 | RET (0.60) | EGFRKDRERBB2ABCG2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |