Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | ILK | Q13418 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978607 | 0.91 | EGFR (0.60) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL7966576 | 0.84 | EGFR (0.57) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL4371491 | 0.82 | RET (0.74) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL4380715 | 0.80 | RET (0.70) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL7980372 | 0.80 | EGFR (0.60) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL7980461 | 0.79 | EGFR (0.61) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL7980714 | 0.79 | EGFR (0.61) | EGFRERBB2RETKDRGAK | |
| SCHEMBL4378156 | 0.79 | KDR (0.71) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL7976753 | 0.79 | CYP1A2 (0.66) | EGFRERBB2KDRFLT1LMNA | |
| SCHEMBL7978595 | 0.78 | EGFR (0.62) | EGFRERBB2RETKDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | claimed |
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |