Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.58 |
| ▸ | EDNRA | P25101 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549097 | 0.94 | EDNRB (0.67) | EDNRBEDNRAKMT2AMEN1MAPT | |
| SCHEMBL8549608 | 0.92 | EDNRB (0.54) | EDNRBEDNRAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6660199 | 0.91 | EDNRB (0.69) | EDNRBEDNRAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8552334 | 0.89 | EDNRB (0.73) | EDNRBEDNRAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8547974 | 0.89 | EDNRB (0.59) | EDNRBEDNRAGRM2 | |
| SCHEMBL8551602 | 0.88 | EDNRB (0.69) | EDNRBEDNRAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8551281 | 0.87 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL8552514 | 0.87 | EDNRB (0.62) | EDNRBEDNRAKMT2AMEN1KDM4E | |
| SCHEMBL8550230 | 0.85 | EDNRB (0.66) | EDNRBEDNRAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8551781 | 0.85 | EDNRB (0.52) | EDNRBEDNRAGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |