Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.52 |
| ▸ | EDNRA | P25101 | 5/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547974 | 0.92 | EDNRB (0.59) | EDNRBEDNRAGRM2GRK2 | |
| SCHEMBL8549390 | 0.92 | EDNRB (0.48) | EDNRBEDNRAPDE10APDE3BPDE3A | |
| SCHEMBL8551777 | 0.90 | EDNRB (0.65) | EDNRBEDNRA | |
| SCHEMBL8552955 | 0.89 | EDNRB (0.52) | EDNRBEDNRA | |
| SCHEMBL8551949 | 0.87 | EDNRB (0.54) | EDNRBEDNRAGRM2GRK2 | |
| SCHEMBL8549097 | 0.87 | EDNRB (0.67) | EDNRBEDNRAGRM2 | |
| SCHEMBL8550953 | 0.86 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8550472 | 0.86 | EDNRB (0.56) | EDNRBEDNRA | |
| SCHEMBL8551944 | 0.85 | EDNRB (0.46) | EDNRBEDNRAPDE10A | |
| SCHEMBL8549138 | 0.85 | EDNRB (0.46) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |