SCHEMBL8552797

SCHEMBL8552797

CCOC(C=O)Oc1ccc(CCc2nnc(C3CCN(C(=O)OCc4ccccc4)CC3)s2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
CYP2C19 P33261 1/20 0.39
TP53 P04637 1/20 0.39
THRB P10828 1/20 0.39
JAK2 O60674 2/20 0.38
JAK1 P23458 2/20 0.38
TYK2 P29597 1/20 0.38
JAK3 P52333 1/20 0.38
GRIN2B Q13224 7/20 0.38
PRMT5 O14744 1/20 0.38
KDM4E B2RXH2 1/20 0.37
USP2 O75604 1/20 0.37
HPGD P15428 1/20 0.37
HSD17B10 Q99714 1/20 0.37
HTT P42858 1/20 0.37
BCL9 O00512 1/20 0.36
CTNNB1 P35222 1/20 0.36
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8552794 0.83 PRMT5 (0.45) SMN1; SMN2NPC1RAB9ACYP2C19JAK2
SCHEMBL8551494 0.75 PRMT5 (0.48) SMN1; SMN2NPC1RAB9ACYP2C19TP53
SCHEMBL23201370 0.71 SMN1; SMN2 (0.58) SMN1; SMN2NPC1RAB9ACYP2C19JAK2
SCHEMBL31169287 0.71 SMN1; SMN2 (0.57) SMN1; SMN2NPC1RAB9ACYP2C19JAK2
SCHEMBL13150409 0.71 SMN1; SMN2 (0.51) SMN1; SMN2NPC1RAB9ACYP2C19JAK2
SCHEMBL8551498 0.69 PRMT5 (0.44) SMN1; SMN2NPC1RAB9ACYP2C19TP53
SCHEMBL8626081 0.67 SMN1; SMN2 (0.51) SMN1; SMN2NPC1RAB9ACYP2C19GRIN2B
SCHEMBL8549063 0.67 TSHR (0.53) SMN1; SMN2NPC1RAB9ACYP2C19GRIN2B
SCHEMBL27035855 0.66 GRIN2B (0.66) SMN1; SMN2NPC1RAB9ACYP2C19JAK2
SCHEMBL26983216 0.66 SMN1; SMN2 (0.53) SMN1; SMN2NPC1RAB9ACYP2C19JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0858457-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM Dr. Karl Thomae GmbH (DE) 1998-08-19 EP disclosed
WO-1997015567-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM DR. KARL THOMAE GMBH (DE) 1997-05-01 WO disclosed