SCHEMBL8549063

SCHEMBL8549063

CCOC(=O)c1sc(C2CCN(C(=O)OCc3ccccc3)CC2)nc1C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.53
ALDH1A1 P00352 2/20 0.53
HTT P42858 2/20 0.53
GAA P10253 1/20 0.53
HSD17B10 Q99714 1/20 0.53
RAB9A P51151 5/20 0.51
NPC1 O15118 5/20 0.51
SMN1; SMN2 Q16637 4/20 0.51
CYP2C19 P33261 1/20 0.49
CSNK1D P48730 1/20 0.48
CASP3 P42574 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
GRIN2B Q13224 3/20 0.46
PRMT5 O14744 1/20 0.45
MAPT P10636 1/20 0.45
HPGD P15428 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8594128 0.91 SMN1; SMN2 (0.55) HTTRAB9ANPC1SMN1; SMN2CYP2C19
SCHEMBL8554226 0.83 SMN1; SMN2 (0.47) TSHRALDH1A1HTTGAAHSD17B10
SCHEMBL3594917 0.82 SMN1; SMN2 (0.51) TSHRALDH1A1HTTGAAHSD17B10
SCHEMBL8626081 0.82 SMN1; SMN2 (0.51) TSHRALDH1A1HTTGAAHSD17B10
SCHEMBL14507429 0.79 SMN1; SMN2 (0.51) TSHRALDH1A1HTTGAAHSD17B10
SCHEMBL2710739 0.78 KMT2A (0.60) TSHRALDH1A1HTTGAAHSD17B10
SCHEMBL20135566 0.78 SMN1; SMN2 (0.51) HTTRAB9ANPC1SMN1; SMN2CYP2C19
SCHEMBL8552781 0.78 LMNA (0.47) ALDH1A1HTTGAARAB9ANPC1
SCHEMBL20135380 0.77 AADAT (0.58) HTTRAB9ANPC1SMN1; SMN2CYP2C19
SCHEMBL17766765 0.76 ALDH1A1 (0.57) TSHRALDH1A1HTTGAAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817677-A ANTITHROMBOSIS AGENTS DR. KARL THOMAE GMBH (DE) 1998-10-06 US disclosed
EP-0858457-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM Dr. Karl Thomae GmbH (DE) 1998-08-19 EP disclosed
WO-1997015567-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM DR. KARL THOMAE GMBH (DE) 1997-05-01 WO disclosed