Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 16/20 | 0.72 |
| ▸ | FPR3 | P25089 | 9/20 | 0.72 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2682776 | 1.00 | FPR2 (0.72) | FPR2FPR3P2RX7CYP3A4CYP2C9 | |
| SCHEMBL15242453 | 1.00 | FPR2 (0.72) | FPR2FPR3P2RX7CYP3A4CYP2C9 | |
| SCHEMBL2682966 | 0.88 | FPR2 (0.76) | FPR2FPR3P2RX7 | |
| SCHEMBL855094 | 0.88 | FPR2 (0.76) | FPR2FPR3P2RX7 | |
| SCHEMBL16674046 | 0.88 | FPR2 (0.76) | FPR2FPR3P2RX7 | |
| SCHEMBL2684126 | 0.88 | FPR2 (0.79) | FPR2FPR3P2RX7 | |
| SCHEMBL6125815 | 0.86 | FPR2 (0.67) | FPR2FPR3P2RX7 | |
| SCHEMBL2682087 | 0.85 | FPR2 (0.72) | FPR2FPR3 | |
| SCHEMBL6125820 | 0.84 | FPR2 (0.65) | FPR2FPR3P2RX7 | |
| SCHEMBL2683054 | 0.84 | FPR2 (1.00) | FPR2FPR3P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640699-A2 | BRIDGED SPIRO[2.4]HEPTANE ESTER DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012066488-A2 | BRIDGED SPIRO[2.4]HEPTANE ESTER DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432760-A1 | BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-28 | — | — | EP | disclosed |