Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CTSG | P08311 | 2/20 | 0.37 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553239 | 0.77 | MAPT (0.40) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8556687 | 0.76 | ELANE (0.56) | ELANETDP1CTSGPRTN3MAPT | |
| SCHEMBL8555608 | 0.72 | ELANE (0.46) | ELANETDP1CTSGPRTN3MAPT | |
| SCHEMBL8557622 | 0.71 | ELANE (0.41) | ELANETDP1CTSGPRTN3ALDH1A1 | |
| SCHEMBL8556267 | 0.69 | ELANE (0.41) | ELANETDP1CTSGPRTN3MAPT | |
| SCHEMBL8555134 | 0.67 | ALDH1A1 (0.37) | MAPTALDH1A1CYP3A4KMT2ASMN1; SMN2 | |
| SCHEMBL8555587 | 0.67 | ELANE (0.54) | ELANETDP1CTSGPRTN3MAPT | |
| SCHEMBL23580135 | 0.67 | ELANE (0.61) | ELANETDP1CTSGPRTN3NPSR1 | |
| SCHEMBL29882726 | 0.66 | ELANE (0.59) | ELANETDP1CTSGPRTN3NPSR1 | |
| SCHEMBL23580631 | 0.66 | ELANE (0.59) | ELANETDP1CTSGPRTN3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |