Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 7/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378752 | 0.81 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL428384 | 0.80 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL14779528 | 0.79 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL7278086 | 0.79 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL12559608 | 0.79 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL19737432 | 0.75 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL8557681 | 0.75 | CYP1A2 (0.47) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL15828561 | 0.75 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL7267699 | 0.73 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 | |
| SCHEMBL1764695 | 0.70 | AHR (0.70) | CYP11B1CYP11B2CYP1A2AHRSRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |