Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 3/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428384 | 0.83 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP1A2SRD5A1AHR | |
| SCHEMBL25066324 | 0.82 | AHR (0.56) | CYP11B1CYP11B2CYP1A2MEN1KMT2A | |
| SCHEMBL7278086 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2SRD5A1AHR | |
| SCHEMBL8553375 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2SRD5A1MEN1 | |
| SCHEMBL14779528 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2SRD5A1AHR | |
| SCHEMBL12559608 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2SRD5A1AHR | |
| SCHEMBL19737432 | 0.78 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2SRD5A1MEN1 | |
| SCHEMBL8557681 | 0.78 | CYP1A2 (0.47) | CYP11B1CYP11B2CYP1A2SRD5A1AHR | |
| SCHEMBL15828561 | 0.78 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2SRD5A1AHR | |
| SCHEMBL7267699 | 0.76 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP1A2SRD5A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| EP-0320992-A2 | Triazolodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |