Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 9/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556558 | 0.81 | SRD5A1 (0.44) | SRD5A1SRD5A2CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL8555700 | 0.81 | SRD5A1 (0.47) | SRD5A1SRD5A2TRPV1CYP11B2CYP11B1 | |
| SCHEMBL8554100 | 0.70 | SRD5A1 (0.39) | SRD5A1SRD5A2TRPV1CYP11B2CYP11B1 | |
| SCHEMBL8555270 | 0.69 | SRD5A1 (0.45) | SRD5A1SRD5A2CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL28114020 | 0.69 | SRD5A1 (0.59) | SRD5A1TRPV1CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL8554102 | 0.68 | SRD5A1 (0.40) | SRD5A1SRD5A2TRPV1CYP11B2CYP11B1 | |
| SCHEMBL8556641 | 0.66 | SRD5A1 (0.55) | SRD5A1TRPV1CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL1744658 | 0.64 | SRD5A1 (0.38) | SRD5A1SRD5A2CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL1746770 | 0.64 | CYP11B2 (0.40) | SRD5A1SRD5A2CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL8553869 | 0.64 | SRD5A1 (0.37) | SRD5A1SRD5A2CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | claimed |