Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 3/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 2/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557760 | 0.85 | TRIM24 (0.38) | TRIM24APOBEC3AAPOBEC3GALDH1A1GAA | |
| SCHEMBL8554978 | 0.79 | ALOX5 (0.46) | TRIM24ALOX5BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL2108940 | 0.78 | TRIM24 (0.36) | TRIM24APOBEC3AAPOBEC3GALDH1A1GAA | |
| SCHEMBL8556602 | 0.75 | TRIM24 (0.36) | TRIM24ALDH1A1GAAALOX5LMNA | |
| SCHEMBL8554039 | 0.74 | ALOX5 (0.51) | TRIM24ALOX5CYP11B1CYP11B2 | |
| SCHEMBL31249742 | 0.69 | TRIM24 (0.46) | TRIM24ALDH1A1GAALMNAPKM | |
| SCHEMBL19224682 | 0.69 | TRIM24 (0.46) | TRIM24ALDH1A1GAALMNAPKM | |
| SCHEMBL8554154 | 0.66 | BRD4 (0.38) | TRIM24APOBEC3AAPOBEC3GALDH1A1GAA | |
| SCHEMBL8558059 | 0.64 | — | — | |
| SCHEMBL2107553 | 0.64 | TRIM24 (0.36) | TRIM24ALDH1A1GAAALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |