Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 9/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CBR1 | P16152 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11413525 | 0.82 | S1PR4 (0.66) | TDP1S1PR4MAPT | |
| SCHEMBL10379872 | 0.82 | TDP1 (0.60) | TDP1S1PR4TSHRMRGPRX4MAPT | |
| SCHEMBL16999887 | 0.82 | MAPT (0.55) | TDP1S1PR4TSHRMAPTHPGD | |
| SCHEMBL3275231 | 0.80 | TDP1 (0.58) | TDP1S1PR4TSHRMRGPRX4MAPT | |
| SCHEMBL8410383 | 0.79 | TDP1 (0.58) | TDP1S1PR4TSHRMAPTHPGD | |
| SCHEMBL8552696 | 0.79 | MRGPRX4 (0.47) | TDP1S1PR4MRGPRX4SLC6A2SLC6A3 | |
| SCHEMBL11840387 | 0.78 | TDP1 (0.56) | TDP1S1PR4TSHRMRGPRX4MAPT | |
| SCHEMBL12360711 | 0.78 | TDP1 (0.56) | TDP1S1PR4TSHRMRGPRX4MAPT | |
| SCHEMBL1547622 | 0.78 | TDP1 (0.56) | TDP1S1PR4TSHRMRGPRX4MAPT | |
| SCHEMBL1547765 | 0.78 | TDP1 (0.56) | TDP1S1PR4TSHRMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859765-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997011060-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-03-27 | — | — | WO | disclosed |