Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252284 | 0.82 | MRGPRX4 (0.48) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 | |
| SCHEMBL12126657 | 0.80 | TSHR (0.51) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 | |
| SCHEMBL17591263 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2A | |
| SCHEMBL8553954 | 0.79 | TDP1 (0.56) | MRGPRX4S1PR4SLC6A2SLC6A3TDP1 | |
| SCHEMBL21601495 | 0.78 | S1PR4 (0.49) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 | |
| SCHEMBL5317553 | 0.77 | S1PR4 (0.48) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 | |
| SCHEMBL21595660 | 0.77 | S1PR4 (0.48) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 | |
| SCHEMBL30025714 | 0.77 | S1PR4 (0.48) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 | |
| SCHEMBL19555362 | 0.77 | S1PR4 (0.48) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 | |
| SCHEMBL5769814 | 0.77 | S1PR4 (0.45) | MRGPRX4S1PR4SLC6A4SLC6A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859765-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997011060-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-03-27 | — | — | WO | disclosed |