Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.60 |
| ▸ | HTR2A | P28223 | 5/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | JUND | P17535 | 1/20 | 0.42 |
| ▸ | FOSB | P53539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876381 | 0.81 | HTR2C (0.49) | HTR2CHTR2AHTR2BADRB2HTR1A | |
| SCHEMBL24509701 | 0.80 | HTR2A (0.50) | HTR2CHTR2AHTR2BADRB2HTR1A | |
| SCHEMBL18324902 | 0.78 | HTR2A (0.52) | HTR2CHTR2AHTR2BHTR1A | |
| SCHEMBL4670703 | 0.78 | HTR2C (0.58) | HTR2CADRB2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL5387687 | 0.78 | SLC6A4 (0.59) | HTR2CHTR2AADRB2HTR1ASLC6A2 | |
| SCHEMBL26965710 | 0.78 | HTR2C (0.58) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL8879510 | 0.78 | NR4A2 (0.50) | HTR2CADRB2 | |
| SCHEMBL17837845 | 0.75 | HTR2C (0.49) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL330081 | 0.75 | HTR2C (1.00) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29891667 | 0.75 | HTR2C (1.00) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |