Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 3/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554103 | 0.81 | HTR2C (0.60) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL23228614 | 0.78 | SLC6A2 (0.66) | HTR2CSLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL24509701 | 0.76 | HTR2A (0.50) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL24510566 | 0.76 | HTR1A (0.56) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL31295202 | 0.76 | HTR1A (0.56) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL31295265 | 0.76 | HTR1A (0.56) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4670703 | 0.74 | HTR2C (0.58) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5387687 | 0.74 | SLC6A4 (0.59) | HTR2CADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL26965710 | 0.74 | HTR2C (0.58) | HTR2CADRB2SLC6A4HTR2AHTR2B | |
| SCHEMBL8879489 | 0.73 | HTR2C (0.54) | HTR2CADRB2IKBKBSLC6A4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172073-B1 | BENZIMIDAZOLYLOXY ALKANAMINES AS SEROTONIN REUPTAKE INHIBITORS; NICOTINE AND TOBACCO WITHDRAWAL; PSYCHOLOGICAL, EATING, BRAIN, GASTROINTESTINAL, SLEEP, AND SEXUAL DISORDERS | ELI LILLY AND COMPANY | 2001-01-09 | — | — | US | disclosed |
| US-5789402-A | Compounds having effects on serotonin-related systems | ELI LILLY COMPANY (US) | 1998-08-04 | — | — | US | disclosed |
| US-5741789-A | HETERO-OXY ALKANAMINES | ELI LILLY AND COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| CN-1178530-A | Compounds having an effect on 5-hydroxytryptamine related systems | LILLY CO ELI (US) | 1998-04-08 | — | — | CN | disclosed |
| US-5627196-A | ANTIDEPRESSANTS AND ANTISEROTONIN AGENTS | ELI LILLY AND COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5614523-A | INDOLYLOXY COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| US-5576321-A | ALKOXY-SUBSTITUTED INDOLES | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |