Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551354 | 0.94 | CHRNB2 (0.39) | SIRT2SIRT3SIRT1CHRNB2CHRNA4 | |
| SCHEMBL8507375 | 0.82 | CHRNB4 (0.36) | — | |
| SCHEMBL8554842 | 0.80 | KDM4E (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL8554469 | 0.78 | IRAK4 (0.40) | NNMTIRAK4 | |
| SCHEMBL8553258 | 0.77 | CHRNB2 (0.41) | CHRNB2CHRNA4 | |
| SCHEMBL8554594 | 0.77 | CHRNB2 (0.41) | CHRNB2CHRNA4 | |
| SCHEMBL12896059 | 0.77 | PARP10 (0.56) | SIRT2SIRT3SIRT1MKNK1MKNK2 | |
| SCHEMBL14131571 | 0.77 | CHRNB2 (0.46) | CHRNB2CHRNA4 | |
| SCHEMBL4961425 | 0.77 | CHRNB2 (0.46) | CHRNB2CHRNA4 | |
| SCHEMBL4961430 | 0.77 | CHRNB2 (0.46) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846114-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1998-06-10 | — | — | EP | claimed |
| WO-1996040682-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1996-12-19 | — | — | WO | claimed |