SCHEMBL8554382

SCHEMBL8554382

C[C@@H](N(CC(=O)O)C(=O)c1ccc(OCC(F)(F)C(F)F)cc1)[C@](O)(Cn1cncn1)c1ccc(Cl)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 10/20 0.39
CYP2C9 P11712 9/20 0.39
CYP2C19 P33261 9/20 0.39
CYP1A2 P05177 6/20 0.39
CYP2D6 P10635 6/20 0.39
KCNH2 Q12809 2/20 0.39
LMNA P02545 2/20 0.34
CYP2B6 P20813 1/20 0.34
CYP3A5 P20815 1/20 0.34
CYP3A7 P24462 1/20 0.34
MAPK1 P28482 1/20 0.34
CYP3A43 Q9HB55 1/20 0.34
CYP46A1 Q9Y6A2 1/20 0.34
PTGS2 P35354 1/20 0.33
KMT2A Q03164 2/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8554388 1.00 CYP3A4 (0.39) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8555073 0.91 CYP3A4 (0.39) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8554860 0.88 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8554855 0.88 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8553576 0.87 CYP3A4 (0.35) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8553580 0.87 CYP3A4 (0.35) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8553145 0.86 CYP3A4 (0.41) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8553143 0.86 CYP3A4 (0.41) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8554392 0.83 CYP3A4 (0.38) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8554072 0.81 CYP3A4 (0.52) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617031-B1 Orally active azole derivates URIACH & CIA SA J (ES) 1998-09-16 EP disclosed
US-5646294-A FUNGICIDES J. URIACH & CIA. S.A. (ES) 1997-07-08 US disclosed
US-5478826-A Fungicides for human, animal and plants J. URIACH & CIA. S.A. (ES) 1995-12-26 US disclosed
EP-0617031-A1 Orally active azole derivates J. URIACH & CIA. S.A. (ES) 1994-09-28 EP disclosed