Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554268 | 0.88 | MAPT (0.51) | MAPTTP53SLC22A12LMNARXFP1 | |
| SCHEMBL7418699 | 0.80 | GAA (0.56) | MAPTSLC22A12LMNAMAP3K14GAA | |
| SCHEMBL7425158 | 0.80 | GAA (0.53) | MAPTTP53SLC22A12LMNAMAP3K14 | |
| SCHEMBL7470357 | 0.79 | MAPT (0.48) | MAPTSLC22A12LMNAMAP3K14GAA | |
| SCHEMBL7419442 | 0.79 | MAPT (0.48) | MAPTSLC22A12LMNAMAP3K14GAA | |
| SCHEMBL7421449 | 0.79 | SMN1; SMN2 (0.56) | MAPTSLC22A12LMNAMAP3K14GAA | |
| SCHEMBL7421590 | 0.77 | GAA (0.53) | MAPTTP53SLC22A12LMNAMAP3K14 | |
| SCHEMBL1995112 | 0.76 | GAA (0.53) | MAPTSLC22A12LMNAMAP3K14GAA | |
| SCHEMBL11830899 | 0.74 | MAPT (0.56) | MAPTTP53SLC22A12LMNAGAA | |
| SCHEMBL10782499 | 0.73 | SLC6A4 (0.48) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |