Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554617 | 0.88 | MAPT (0.52) | MAPTTP53SLC22A12LMNAMEN1 | |
| SCHEMBL7422870 | 0.82 | MAPT (0.55) | MAPTTP53SLC22A12LMNAMEN1 | |
| SCHEMBL7425520 | 0.81 | MAPT (0.52) | MAPTTP53SLC22A12LMNAMEN1 | |
| SCHEMBL7470611 | 0.81 | MAPT (0.52) | MAPTTP53SLC22A12LMNAMEN1 | |
| SCHEMBL7467136 | 0.80 | TSHR (0.48) | MAPTTP53SLC22A12LMNAMEN1 | |
| SCHEMBL7421750 | 0.78 | CNR2 (0.45) | MAPTTP53SLC22A12LMNAMEN1 | |
| SCHEMBL7421205 | 0.73 | L3MBTL1 (0.62) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL7472560 | 0.73 | MAPT (0.49) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL28566459 | 0.73 | PLAU (0.52) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL30185536 | 0.73 | PLAU (0.52) | MAPTTP53LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |