SCHEMBL8554777

SCHEMBL8554777

O=C(c1ccccc1)N1CCC(CSc2ccccc2)CC1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.56
LMNA P02545 3/20 0.53
HPGD P15428 2/20 0.53
ALDH1A1 P00352 2/20 0.53
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
HDAC3 O15379 1/20 0.53
HDAC4 P56524 1/20 0.53
HDAC1 Q13547 1/20 0.53
HDAC7 Q8WUI4 1/20 0.53
HDAC2 Q92769 1/20 0.53
HDAC10 Q969S8 1/20 0.53
HDAC11 Q96DB2 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
HDAC9 Q9UKV0 1/20 0.53
HDAC5 Q9UQL6 1/20 0.53
EPHX1 P07099 1/20 0.52
L3MBTL3 Q96JM7 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15477388 0.86 SMN1; SMN2 (0.48) HPGDALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL3459209 0.80 ACHE (0.65) ACHEHPGDHDAC3HDAC4HDAC1
SCHEMBL5179706 0.78 ACHE (0.63) ACHEHPGDALDH1A1HDAC3HDAC4
SCHEMBL3458901 0.78 ACHE (0.63) ACHEHPGDHDAC3HDAC4HDAC1
SCHEMBL2618044 0.78 ACHE (0.68) ACHEHPGDALDH1A1SMN1; SMN2HDAC3
SCHEMBL10762328 0.78 ACHE (0.63) ACHEHPGDHDAC3HDAC4HDAC1
SCHEMBL6158231 0.78 ACHE (0.63) ACHEHPGDSMN1; SMN2HDAC3HDAC4
SCHEMBL7232379 0.77 HTT (0.73) RAB9AMEN1KMT2AHTTCA12
SCHEMBL7320522 0.77 HDAC3 (0.64) ACHEHPGDHDAC3HDAC4HDAC1
SCHEMBL3458030 0.77 HDAC3 (0.64) ACHEHPGDHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP disclosed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US disclosed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO disclosed