Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554815 | 1.00 | POLB (0.39) | POLBLMNATP53CASP3MEN1 | |
| SCHEMBL9487615 | 0.92 | POLB (0.39) | POLBLMNATP53CASP3MEN1 | |
| SCHEMBL9487619 | 0.92 | POLB (0.39) | POLBLMNATP53CASP3MEN1 | |
| SCHEMBL8559790 | 0.84 | MEN1 (0.45) | POLBLMNAMEN1CYP1A2KMT2A | |
| SCHEMBL8559793 | 0.84 | MEN1 (0.45) | POLBLMNAMEN1CYP1A2KMT2A | |
| SCHEMBL8553818 | 0.83 | POLB (0.36) | POLBLMNACASP3MEN1CYP1A2 | |
| SCHEMBL8553820 | 0.83 | POLB (0.36) | POLBLMNACASP3MEN1CYP1A2 | |
| SCHEMBL9256647 | 0.82 | LMNA (0.37) | POLBLMNATP53CASP3CYP1A2 | |
| SCHEMBL9256639 | 0.82 | LMNA (0.37) | POLBLMNATP53CASP3CYP1A2 | |
| SCHEMBL8014028 | 0.81 | SMN1; SMN2 (0.43) | POLBLMNATP53MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395219-B1 | Cephalosporins and their homologues, process for their preparation and pharmaceutical compositions | PFIZER (US) | 1998-09-30 | — | — | EP | disclosed |
| US-5246926-A | Bactericides | BEECHAM GROUP P.L.C. (GB) | 1993-09-21 | — | — | US | disclosed |
| EP-0395219-A2 | Cephalosporins and their homologues, process for their preparation and pharmaceutical compositions | Beecham Group p.l.c. (GB) | 1990-10-31 | — | — | EP | disclosed |