Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.64 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31351129 | 0.81 | GLS (0.41) | GLSKMOMAPTPKMKMT2A | |
| SCHEMBL2933655 | 0.81 | GLS (0.75) | GLSKMOMAPTPOLBATM | |
| SCHEMBL521026 | 0.80 | GLS (0.65) | GLSMAPTPOLBALDH1A1PKM | |
| SCHEMBL8555760 | 0.79 | CHEK1 (0.43) | GLSKMOCYP1A2 | |
| SCHEMBL14928249 | 0.78 | GLS (0.75) | GLSKMOMAPTPOLBATM | |
| SCHEMBL10982770 | 0.78 | GLS (0.70) | GLSKMOMAPTPOLBATM | |
| SCHEMBL2075325 | 0.77 | GLS (0.68) | GLSALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL15508908 | 0.76 | GLS (0.55) | GLSMAPTPOLBALDH1A1PKM | |
| SCHEMBL31251358 | 0.76 | GLS (0.57) | GLSMAPTALDH1A1CYP1A2 | |
| SCHEMBL2429058 | 0.76 | GLS (0.64) | GLSMAPTPOLBALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |