Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855175 | 0.90 | NUAK1 (0.36) | NUAK1IGF1RMETPIM1SRC | |
| 4,5,6,7-Tetrachlorophthalide SCHEMBL8408571 | 0.83 | ALDH1A1 (0.44) | NUAK1IGF1RMETPIM1SRC | |
| 4,5,6,7-Tetrachlorophthalide SCHEMBL27454 | 0.83 | ALDH1A1 (0.44) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL855596 | 0.82 | NUAK1 (0.36) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL856180 | 0.76 | NUAK1 (0.35) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL854136 | 0.74 | NUAK1 (0.39) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL855516 | 0.72 | EPAS1 (0.34) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL20008085 | 0.69 | NUAK1 (0.36) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL855177 | 0.68 | NUAK1 (0.35) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL855131 | 0.66 | TSHR (0.57) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433933-B1 | PRODUCTION METHOD OF TRI- OR TETRAHALOGEN-SUBSTITUTED PHTHALIDE | SUMITOMO CHEMICAL CO (JP) | 2019-05-08 | — | — | EP | disclosed |
| US-8604221-B2 | Production method of halogen-substituted phthalide | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-12-10 | — | — | US | disclosed |
| US-20120142946-A1 | PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-06-07 | — | — | US | disclosed |
| EP-2433933-A1 | PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE | Sumitomo Chemical Company, Limited (JP) | 2012-03-28 | — | — | EP | disclosed |