Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552562 | 0.90 | SNCA (0.36) | SNCAKMT2AMEN1CYP3A4CA1 | |
| SCHEMBL27511864 | 0.85 | SNCA (0.41) | SNCAKMT2AMEN1CYP3A4CA1 | |
| SCHEMBL8300761 | 0.78 | SNCA (0.42) | SNCAKMT2AMEN1CYP3A4CA1 | |
| SCHEMBL27511532 | 0.71 | SMN1; SMN2 (0.44) | KMT2AMEN1CYP3A4CA1CA2 | |
| SCHEMBL27484039 | 0.70 | SNCA (0.51) | SNCAKMT2AMEN1CYP3A4ALDH1A1 | |
| SCHEMBL175786 | 0.69 | SNCA (0.67) | SNCAKMT2AMEN1CYP3A4CA1 | |
| SCHEMBL8305094 | 0.69 | SNCA (0.43) | SNCAKMT2AMEN1CYP3A4ALDH1A1 | |
| SCHEMBL8305671 | 0.69 | SNCA (0.38) | SNCAKMT2AMEN1CYP3A4CA1 | |
| SCHEMBL10590383 | 0.68 | SNCA (0.55) | SNCAKMT2AMEN1CYP3A4CA1 | |
| SCHEMBL31222822 | 0.68 | SNCA (0.49) | SNCAKMT2AMEN1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |