Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555621 | 0.90 | SNCA (0.39) | SNCACA1CA2CYP3A4ALDH1A1 | |
| SCHEMBL27511864 | 0.82 | SNCA (0.41) | SNCAEPHX1CA1CA2CYP3A4 | |
| SCHEMBL8300761 | 0.75 | SNCA (0.42) | SNCACA1CA2CYP3A4ALDH1A1 | |
| SCHEMBL27511532 | 0.71 | SMN1; SMN2 (0.44) | CA1CA2CYP3A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL8305094 | 0.68 | SNCA (0.43) | SNCAEPHX1CYP3A4ALDH1A1KDM4E | |
| SCHEMBL2705494 | 0.68 | SNCA (0.58) | SNCACA1CA2CYP3A4ALDH1A1 | |
| SCHEMBL8720293 | 0.68 | SNCA (0.36) | SNCAEPHX1CYP3A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL8652713 | 0.68 | EPHX1 (0.36) | SNCAEPHX1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8301034 | 0.68 | SNCA (0.49) | SNCACA1CA2CYP3A4ALDH1A1 | |
| SCHEMBL27484039 | 0.68 | SNCA (0.51) | SNCACYP3A4ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |