Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD5 | P21918 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042440 | 0.88 | POLB (0.68) | MEN1KMT2APOLBKDM4ECNR1 | |
| SCHEMBL3454630 | 0.82 | USP2 (0.67) | POLBKDM4EABCB1CYP2D6ALDH1A1 | |
| SCHEMBL16676773 | 0.79 | ABCB1 (0.66) | MEN1KMT2APOLBKDM4ECNR1 | |
| SCHEMBL21681926 | 0.79 | POLB (0.62) | MEN1KMT2APOLBKDM4ECNR1 | |
| SCHEMBL1874443 | 0.78 | KDM4E (0.64) | POLBKDM4ECNR1CNR2DRD1 | |
| SCHEMBL8643914 | 0.78 | DRD2 (0.60) | MEN1KMT2APOLBKDM4EDRD1 | |
| SCHEMBL6044278 | 0.77 | MEN1 (0.72) | MEN1KMT2APOLBKDM4ECNR1 | |
| SCHEMBL5043172 | 0.77 | POLB (0.60) | MEN1KMT2APOLBKDM4EDRD1 | |
| SCHEMBL21681985 | 0.77 | NPC1 (0.63) | POLBKDM4ECNR1CNR2DRD1 | |
| SCHEMBL16674495 | 0.76 | POLB (0.62) | MEN1KMT2APOLBKDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0813534-A4 | 6-ARYL PYRAZOLO 3,4-d]PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-06-10 | — | — | EP | disclosed |
| EP-0813534-A1 | 6-ARYL PYRAZOLO 3,4-d]PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI PHARMACEUTICALS, INC. (US) | 1997-12-29 | — | — | EP | disclosed |