Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663983 | 0.94 | MAPKAPK2 (0.49) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL8608335 | 0.87 | MAPKAPK2 (0.42) | HTR1BHTR1DMAPKAPK2EGFRIGF1R | |
| SCHEMBL7662787 | 0.86 | HTR1B (0.53) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL8559020 | 0.82 | EGFR (0.50) | HTR1BHTR1DMAPKAPK2EGFRIGF1R | |
| SCHEMBL24408396 | 0.79 | HTR1B (0.57) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL7655639 | 0.77 | HTR1D (0.50) | HTR1BHTR1DMAPKAPK2EGFRIGF1R | |
| SCHEMBL11418263 | 0.76 | MCHR1 (0.49) | — | |
| SCHEMBL834332 | 0.76 | MEN1 (0.53) | HTR1AHTR1BHTR1D | |
| SCHEMBL1905530 | 0.76 | MEN1 (0.53) | HTR1AHTR1BHTR1D | |
| SCHEMBL834331 | 0.76 | MEN1 (0.53) | HTR1AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708187-A | MIGRANE HEADACHES | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |