Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95231 | 0.90 | KCNH2 (0.34) | CYP3A4ATMDYRK1ADYRK1B | |
| SCHEMBL2544184 | 0.82 | ALDH1A1 (0.46) | DYRK1ADYRK2DYRK1BCHRM2CHRM1 | |
| SCHEMBL28902687 | 0.81 | CHRM2 (0.43) | CYP3A4ATMDYRK1ADYRK2DYRK1B | |
| SCHEMBL8577915 | 0.76 | ALDH1A1 (0.34) | — | |
| SCHEMBL11521104 | 0.72 | ALDH1A1 (0.43) | DYRK1ADYRK1B | |
| SCHEMBL1122453 | 0.72 | MAPT (0.40) | DYRK1A | |
| SCHEMBL71411 | 0.71 | OGA (0.35) | — | |
| SCHEMBL20558808 | 0.70 | DYRK1A (0.57) | DYRK1ADYRK2DYRK1B | |
| SCHEMBL1573303 | 0.68 | CHRM2 (0.36) | CYP3A4CHRM2CHRM1CHRNB2CHRM3 | |
| SCHEMBL25842041 | 0.68 | CHRM2 (0.36) | CHRM2CHRM1CHRNB2CHRM3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858452-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | disclosed |
| WO-1998004536-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-02-05 | — | — | WO | disclosed |