Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | EDNRA | P25101 | 9/20 | 0.36 |
| ▸ | EDNRB | P24530 | 8/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557361 | 0.75 | EDNRA (0.43) | HSD17B10RAB9AEDNRAEDNRBABCC3 | |
| SCHEMBL8557046 | 0.68 | EDNRA (0.42) | HSD17B10RAB9AEDNRAEDNRBPKM | |
| SCHEMBL8557591 | 0.67 | EDNRA (0.44) | HSD17B10RAB9AEDNRAEDNRBABCC3 | |
| SCHEMBL8627060 | 0.66 | EDNRA (0.42) | HSD17B10RAB9AEDNRAEDNRBABCC3 | |
| SCHEMBL8561556 | 0.65 | EDNRA (0.44) | HSD17B10RAB9AEDNRAEDNRBABCC3 | |
| SCHEMBL7949184 | 0.64 | EDNRA (0.50) | HSD17B10RAB9AEDNRAEDNRBABCC3 | |
| SCHEMBL7946892 | 0.60 | EDNRA (0.49) | HSD17B10RAB9AEDNRAEDNRBABCC3 | |
| SCHEMBL6314152 | 0.60 | EDNRA (0.66) | HSD17B10RAB9AEDNRAEDNRBABCC3 | |
| SCHEMBL8629983 | 0.60 | EDNRA (0.48) | RAB9AEDNRAEDNRBPKMABCC3 | |
| SCHEMBL8556595 | 0.60 | EDNRA (0.49) | HSD17B10RAB9AEDNRAEDNRBABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885219-A1 | N-(2,1,3-BENZOTHIA(OXA)DIAZOLYL)-SULPHONAMIDES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997030996-A1 | N-(2,1,3-BENZOTHIA(OXA)DIAZOLYL)-SULPHONAMIDES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-08-28 | — | — | WO | disclosed |