Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.42 |
| ▸ | EDNRB | P24530 | 16/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557591 | 0.89 | EDNRA (0.44) | EDNRAEDNRBRAB9AHSD17B10ABCC3 | |
| SCHEMBL8557361 | 0.88 | EDNRA (0.43) | EDNRAEDNRBRAB9AHSD17B10ABCC3 | |
| SCHEMBL8561556 | 0.86 | EDNRA (0.44) | EDNRAEDNRBRAB9AHSD17B10ABCC3 | |
| SCHEMBL8557046 | 0.85 | EDNRA (0.42) | EDNRAEDNRBRAB9AHSD17B10ABCC3 | |
| SCHEMBL8556595 | 0.75 | EDNRA (0.49) | EDNRAEDNRBRAB9AHSD17B10ABCC3 | |
| SCHEMBL6313203 | 0.71 | EDNRA (0.63) | EDNRAEDNRBRAB9AHSD17B10ABCC3 | |
| SCHEMBL8629235 | 0.69 | EDNRA (0.49) | EDNRAEDNRBRAB9AHSD17B10 | |
| SCHEMBL7947366 | 0.68 | EDNRA (0.60) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7949184 | 0.67 | EDNRA (0.50) | EDNRAEDNRBRAB9AHSD17B10ABCC3 | |
| SCHEMBL8563724 | 0.66 | ALDH1A1 (0.44) | EDNRAEDNRBRAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885219-A1 | N-(2,1,3-BENZOTHIA(OXA)DIAZOLYL)-SULPHONAMIDES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997030996-A1 | N-(2,1,3-BENZOTHIA(OXA)DIAZOLYL)-SULPHONAMIDES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-08-28 | — | — | WO | disclosed |