Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.56 |
| ▸ | PDE4A | P27815 | 14/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.56 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353005 | 0.75 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7357381 | 0.73 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7352641 | 0.73 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6589467 | 0.72 | PDE4B (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6584467 | 0.70 | PDE4B (0.78) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361766 | 0.69 | CYP1A1 (0.47) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361769 | 0.69 | CYP1A1 (0.47) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14804191 | 0.69 | SLC6A4 (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6588075 | 0.68 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL12180595 | 0.67 | PDE4D (0.58) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |