Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395757 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL14455896 | 0.78 | PDE4A (0.84) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7400689 | 0.77 | PDE4A (0.81) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL84865 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7369940 | 0.76 | PDE4A (0.80) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7374697 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7401440 | 0.75 | PDE4A (0.79) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7376577 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7398485 | 0.74 | PDE4A (0.96) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL8556013 | 0.74 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738270-B1 | DIHYDRO PYRAZOLOPYRROLES | PFIZER (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5596013-A | INHIBITORS OF PHOSPHODIESTERASE TYPE IV AND PRODUCTION OF TUMOR NECROSIS FACTOR | PFIZER INC (US) | 1997-01-21 | — | — | US | disclosed |
| US-5508300-A | INHIBIT PHOSPHODIESTERASE AND PRODUCTION OF TUMOR NECROSIS FACTOR; TREATING INFLAMMATORY DISEASES | PFIZER INC. (US) | 1996-04-16 | — | — | US | disclosed |