Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556985 | 1.00 | KDM4E (0.48) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7463308 | 1.00 | KDM4E (0.48) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7469204 | 0.92 | LMNA (0.47) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7471681 | 0.89 | KDM4E (0.42) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7474971 | 0.86 | TNFRSF1A (0.49) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7473014 | 0.81 | LMNA (0.48) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7469594 | 0.81 | LMNA (0.46) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7469785 | 0.80 | KDM4E (0.40) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7469782 | 0.80 | KDM4E (0.40) | KDM4EHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7466065 | 0.79 | LMNA (0.42) | KDM4EHTTL3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858452-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | disclosed |
| WO-1998004536-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-02-05 | — | — | WO | disclosed |